stomics spatial transcriptomics platform (Spatial Transcriptomics Inc)
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Stomics Spatial Transcriptomics Platform, supplied by Spatial Transcriptomics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/stomics spatial transcriptomics platform/product/Spatial Transcriptomics Inc
Average 90 stars, based on 1 article reviews
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1) Product Images from "Application of Spatial Omics in the Cardiovascular System"
Article Title: Application of Spatial Omics in the Cardiovascular System
Journal: Research
doi: 10.34133/research.0628
Figure Legend Snippet: Schematic principle and workflow of spatial omics in cardiovascular research. (A) Spatial transcriptomics: Mapped gene expression patterns in cardiovascular tissues, identifying specific gene signatures in different heart regions. Sequencing-based methods are illustrated using the principles of Visium as an example, while imaging-based methods are represented by the principles of Xenium. Slight variations in principles may exist across different technologies. (B) Spatial proteomics: Analyzed protein distributions and interactions, revealing protein networks and spatial organization within cardiac tissues. Antibody-dependent spatial MS methods are illustrated using the principles of GeoMx DSP as an example, while cyclic antibody imaging-based methods are represented by the principles of PCF and CODEX. Slight variations in principles may exist across different technologies. (C) Spatial metabolomics: Provided high-resolution metabolite profiling, revealing metabolic alterations and spatial distributions in cardiovascular tissues. (D) Spatial epigenomics: Profiled chromatin accessibility, histone modifications, and DNA methylation patterns, providing insights into epigenetic landscapes in cardiac cells. (E) Spatial genomics: Studied the spatial arrangement of genetic material within cell nuclei, revealing the 3D genome organization and its impact on cellular function. Created with BioRender.
Techniques Used: Gene Expression, Sequencing, Imaging, Spatial Proteomics, DNA Methylation Assay, Cell Function Assay
Figure Legend Snippet: Summary of the commonly used method of spatial omics technologies
Techniques Used: Sequencing, Imaging, Formalin-fixed Paraffin-Embedded, Expressing, In Situ, High Throughput Screening Assay, Spatial Proteomics, Multiplexing, Fluorescence, Microscopy, Modification
Figure Legend Snippet: Comparative summary of sample preparation for spatial omics technologies
Techniques Used: Sample Prep, Preserving, Modification, Spatial Proteomics, Imaging, Mass Cytometry
Figure Legend Snippet: Schematic view of cardiovascular diseases using spatial transcriptomics. (A) Atherosclerosis: Showed high macrophage infiltration and molecular signatures related to plaque stability within atherosclerotic plaques. (B) Myocardial infarction: Displayed distinct gene expression patterns in infarcted and peri-infarct zones, highlighting molecular responses to ischemic injury. (C) Cardiomyopathy: Revealed fibrosis-related genes and altered cellular composition in HCM tissues. (D) Heart failure: Uncovered region-specific gene expression changes that contribute to the progression of HF. (E) Aortic dissection: Highlighted distinct molecular profiles in dissection sites, providing insights into pathophysiology and potential therapeutic targets. (F) Cardiac myxoma: Identified tumor-specific gene signatures and interactions within the tumor microenvironment. CM, cardiomyocyte; FB, fibroblast; Mac, macrophage; SMC, smooth muscle cell; ETC, EC-like tumor cells; MTC, MSC-like tumor cells. Created with http://BioRender.com .
Techniques Used: Gene Expression, Dissection, Biomarker Discovery
Figure Legend Snippet: Summary of spatial transcriptomics in the research of cardiovascular diseases
Techniques Used: Expressing, Gene Expression, Marker, Infection, Activation Assay, Transformation Assay